PSI
Wait and see, and grow crystals
Research
PSI
At PSI, researchers decipher the structure of the proteins in bacteria and viruses. This knowledge can aid, for example, in the development of drugs against infectious diseases. But before the investigation can begin, an extremely tricky problem has to be solved: the crystallisation of the molecules.
A protein's unexpected "doming"
Research
PSI
Researchers have coaxed a secret out of the vital protein cytochrome c that it kept well-hidden up to now. Measurements at the X-ray free-electron laser SwissFEL reveal structural changes that science had previously ruled out for this kind of biomolecule.
Measurements at PSI enabled detailed understanding of genetic scissors
Research
PSI
PSI congratulates Emmanuelle Charpentier and Jennifer Doudna on winning this year's Nobel Prize in Chemistry. Experiments at the Swiss Light Source SLS in 2013 made it possible to elucidate the structure of the protein complex CRISPR-Cas9 and thus to better understand its function as genetic scissors.
More effective treatment of thyroid cancer
Research
PSI
PSI researchers have found a more effective treatment for a form of thyroid cancer – and with fewer side effects – by increasing the uptake of the cancer drug in tumour cells. The results have been published in the medical journal Theranostics.
"We were shocked how far advanced the melting is already"
Research
PSI
An international expedition with the participation of the Paul Scherrer Institute PSI discovers advanced glacial melting at an elevation of more than 4,000 metres on the Grand Combin in Valais. In the Alps, it may almost be too late for the Ice Memory project, which aims to save ice cores as a climate archive for future generations of researchers.
Mites in the spotlight
Research
PSI
The world of microbes and viruses is extremely old and exceedingly diverse. With the large research facilities at PSI, researchers are peering deep inside this alien cosmos and investigating, above all, the proteins of these exotic beings.
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